To answer your question what do you say? Anything you say spoken with compassion, and sincerity will be fine. Understanding this is not something that will truly ever pass. One thing you can do is to be there for them and be supportive and try to help them adjust to a new normal. praying for you and yours that God gives you the strength to get through it.
I try and email her every week. They are taking life one day at a time. She said she is waiting to see if things get brighter. She said her life seems a monochrome grey!