So, what is going on with your dog's sample? Read on for the details:
First, our scientists delve into Tallulah's cells to pull out all the doggy DNA they can (this step even includes robots). Then the sample goes through several steps of purification to remove everything else. Next, with the help of some enzymes and a machine called a thermocycler, we amplify your dog's DNA up to a million times. Without this machine, we might have needed a gallon of saliva from Tallulah to get the DNA profile, and nobody wants that. Seriously, this machine is amazing! After that comes the genotyping, which we will tell you about in our next email.
The second step in our process is when the DNA sample undergoes genotyping.
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Our genomicists look at over 200,000 genetic addresses in the doggie genome to discover more about each DNA sample we extract. For more details, you can read on below.
The results should be ready within a week or two. In some cases where a dog has especially complicated genetics it can take a little longer to complete, as we check and double-check every result.
We will continue to update you as we explore each and every chromosome — and your dog has 78 of them, unlike you and I who have only 46 each!
So, what is going on with your dog’s DNA sample? Read on for the details:
In order to figure out what genetic letter your dog has at over 200,000 different addresses in their genome, Embark scientists are analyzing millions of copies of your dog’s DNA using our advanced genetic “chip”. The “chip”, more accurately called a microarray, is Embark’s core proprietary technology. Designed by Embark scientists, our technology will allow Embark and other researchers all over the world to make exciting new discoveries in dog health. Embark scientists have distilled years of knowledge about the links between genes and breeds, diseases and traits in dogs, and have added many special probes (essentially genetic addresses) to the chip. The chip tells the machine which genetic addresses to look up, and then the machine takes apart your dog’s DNA at those locations to reveal whether your dog inherited an A, T, C, or G at that exact location from each parent. This information is what our genomicists use to understand your dog at the detailed chromosome level. If that was too much science talk, we apologize, but we can't help ourselves!
As you anxiously await your dog's breed results, listen to our Chief Science Officer talk about some Embark dogs with surprising results, and the science behind how this can happen.
If you have opted in to contribute to research, Tallulah’s genetic data will power new advances in dog health and keep advancing the science of dog wellness. Very cool!